生物製藥研究所 > 蛋白質特性分析組

關於我們

可提供客製化服務生技蛋白藥物開發不同階段: 由研發蛋白質轉譯修飾分析、先導藥物及候選藥物的選擇,至生產製程應用:蛋白質工程、細胞表現和下游製程,配方開發和安定性分析,原料藥及產品的特性鑑定。

 

服務介紹

蛋白質結構與鑑定(protein structure and identification),醣基化模式(glycan profile and glycosylation site),物化特性分析(physicochemical properties),品管(quality control)、純度(purity)、不純物(impurities)、凝集(aggregates)。

 

Structural characterization and confirmation

 • Amino acid sequence

 • Terminal amino acid sequence:N/C

 • Peptide map

 • Sulfhydryl groups and disulfide bridges

 • Carbohydrate structure/Glycosylation

 

Physicochemical properties

 • Molecular weight or size

 • Isoform pattern

 • Extinction coefficient (EC)

 • Glycan profile

 • Electrophoretic patterns

 • Liquid chromatographic patterns

 • Spectroscopic Profiles

 

Process- and product-related impurities

 • Host cell proteins

 • Host cell DNA

 • Truncated forms

 • Post-translational modifications: e.g.,deamidated, isomerized, mismatched S-S linked, oxidized or altered conjugated forms

 • Aggregates

 


 

聯絡窗口

姓名:鄭惠娟

職稱:研究員

單位:生物製藥研究所

Email:hjjeng@dcb.org.tw

電話:02-2695 6933 分機:2431