研究發展 可技轉技術

Technology/ Title

Development of anti-Globo H ADC against Cancer

Technology Type

□Biotechnology

□Device/Diagnostics

■Pharmaceutical

□Others:_____________-

Contact Person

Name: Joseph Liu

Title: Project Manager

Telephone(work): +886-02-7700-3800  ext. 5237

Mobile:

Email: joseph.liu@dcb.org.tw

Link

http://

Technology Description

Summary of Invention:

1.      Antibody-drug conjugates (ADC) is one of the most important approach in recent cancer drug development. ADCs contain an antibody and high potent cytotoxic drugs and these two parts are connected with a specific linker. ADCs can target to the tumor cells through the antibody part by recognizing and binding to correspond tumor antigen. After internalization, the ADCs was cleaved or digested in lysosome or endosome and cytotoxic drugs were released to kill the cancer cells.

2.      The ADC candidate compound show great tumor inhibition via a novel target, and belongs to first-in-class drug development.

Advantages when compared to the existing technologies:

1. In vitro & in vivo platforms for ADC screening.
2. Novel site-specific conjugation method for ADC products.
3. Characterization and analytical platforms for ADC.
4. Pre-clinical development ADC candidate with novel targeting antibody.

Intellectual Property

US, PCT, Taiwan patent were filed

Key Publications

Business Opportunity

Next generation antibody related in cancer therapy