Technology/ Title

Development of Tissue Specific Activated Antibody for Central Nervous System (CNS) Related Diseases

Technology Type

Biotechnology

Device/Diagnostics

Pharmaceutical

Others:_____________-

Contact Person

Name: Tony Chung

Title: Project Manager

Telephone(work): +886-02-7700-3800  ext. 5235

Mobile:

Email: tony.chung@dcb.org.tw

Link

http://

 

 

Technology Description

 

Summary of Invention:

Antibodies are highly specific to their target antigens with high affinities, and have been approved for therapeutic or diagnostic applications in some diseases. However, the target antigen expression is not necessarily disease-specific. Therefore, most therapeutic antibodies will also target normal tissues in addition to targeting the disease lesions, thereby causing adverse effects. In this invention, antibody activity is reduced by the N-terminal fused blocker which can be cleaved by a CNS specific protease. The antigen recognition ability of the antibody is reduced in peripheral blood, hence the therapeutic antibody for CNS-related diseases will not target the tissue outside the CNS and cause adverse effect.

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Advantages when compared to the existing technologies:

  1. CNS-specific activation
  2. Lower adverse effect expected

Intellectual Property

TW, US, PCT patents applied

Key Publications

 

 

Business Opportunity

CNS-related Diseases Therapy

CNS-related cancer, inflammatory disease, autoimmune disease, infectious disease, and neuron degeneration disease

 

 

 

▌技術簡介(現況)

抗體藥物雖然對其抗原有高度的專一性,然而該抗原往往不是只有在疾病發生的組織才有表現,所以具專一性的抗體藥物仍會產生不期望的副作用。因此,為了降低抗體在周邊血循環過程中所產生之副作用,本開發平台在抗體藥物N端接上一段可被蛋白酶所切斷之阻斷物,用以抑制抗體藥物在周邊血中的活性。由於所篩選之蛋白酶具有在腦內大量表現的特性,待此抗體進入中樞神經系統後,該蛋白酶便可將N端的阻斷物切除,進而活化抗體辨認抗原的能力,以達成降低副作用及疾病治療之功效。

 

▌技術規格

組織專一性活化之中樞神經系統疾病抗體藥物開發平台

 

▌技術特色

中樞神經系統專一性活化之抗體具有在周邊血中低活性,並可在中樞神經系統被活化的特性,此開發平台可降低中樞神經系統疾病治療抗體藥物在周邊血中所產生的副作用,提高抗體藥物的臨床應用性及競爭力

 

▌應用範圍

中樞神經系統相關癌症、發炎疾病、自體免疫疾病、神經退化疾病等之治療。

 

▌接受技術者具備基礎建議(設備)

一般分子生物學實驗設施、抗體表現與純化系統。

 

▌接受技術者具備基礎建議(專業)

抗體臨床前開發技能。

 

▌技術分類

抗體藥物開發。

 

▌專利狀態

已申請專利國家: 美國、PCT、中華民國


聯絡人:鍾牧樺

TEL(02)7700-3800 #5235

E-mailtony.chung@dcb.org.tw

最後更新日期:2019.03.27